WebNov 30, 2009 · BubR1 also has a third function, promoting proper kinetochore–microtubule (MT [K–MT]) linkages (Lampson and Kapoor, 2005). This multifunctionality makes the phenotypes resulting from BubR1 inactivation difficult to interpret. For example, it is not known to what extent these different activities are interdependent. WebDec 8, 2024 · BUBR1 is essential for early embryonic development and normal hematopoiesis BubR1 and Apc functionally interact in regulating metaphase-anaphase transition, deregulation of which may play a key role in genomic instability and development and progression of colorectal cancer.
BubR1 is a spindle assembly checkpoint protein regulating ... - PubMed
WebApr 14, 2024 · A total of 8331 tumors and 24 cancer types from TCGA were included in the study. The cohort was divided into tumors harboring non-synonymous TP53 mutations in the coding sequence or at splice ... WebBubR1. In the early 1990s, yeast genetic screening identified a series of genes that are required for spindle checkpoint control. 5–7 These genes are highly conserved in higher animals and function as key components of the spindle checkpoint. We, and others, have cloned and characterized human BUB1 (hBUB1) and BUBR1 (hBUBR1 or hMAD3), … dollar general southport nc
701 - Gene ResultBUB1B BUB1 mitotic checkpoint …
WebFeb 25, 2016 · Bub1 is a multifunctional component of the spindle checkpoint ( Fig. 1a ). However, it was difficult to produce checkpoint defects in human cells depleted of Bub1 with RNA interference (RNAi) (... WebJul 15, 2010 · Pharicin A induces mitotic arrest in leukemia and solid tumor-derived cells identified by their morphology, DNA content and mitotic marker analyses. Pharicin A-induced mitotic arrest is associated with unaligned chromosomes, aberrant BubR1 localization and deregulated spindle checkpoint activation. WebIn this study, we investigated the role of BubR1 in behavioral function. Methods: To assess anxiety-like behavior, the above groups were subjected to the elevated plus maze and … dollar general spears creek church road